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The first segment after the Yakko, Wakko, and Dot segment, Pinky and the Brain is about two lab mice, Pinky and Brain, who try to take over the world every night. Pinky And The Brain has as much set jokes as the main segment, like the Are You Pondering What I'm Pondering? routine and Pinky often saying nonsense words like "Narf!", "Zort!" and "Troz!". In fact, it got so popular with fans, it gained its own spin-off show and had a short-lived comic book series.

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