Looney Tunes is a series of cartoons which are the backbone of Warner Bros. Since Looney Tunes and Animaniacs are owned by Warner Bros., it is not uncommon for Looney Tunes references to appear on the show.
- Probably the most prominent appearances are in Slappy Squirrel, where the title character starred in fictious Looney Tunes cartoons.
- Bugs Bunny, Daffy Duck, Foghorn Leghorn, Yosemite Sam, and Tweety all appear in The Warners 65th Anniversary Special.
- Daffy Duck and Tweety are mentioned in a song in Episode 3: H.M.S. Yakko/Slappy Goes Walnuts/Yakko's Universe.
- Porky Pig appears in a flashback in De-Zanitized.
- Tweety and Daffy Duck can be seen in Star Warners.
- Road Runner & Wile E. Coyote made a cameo in "Little Old Slappy from Pasadena" and "Bumbie's Mom"
- Wile E. Coyote appears in "Buttons in Ows"..
- Yosemite Sam also appeared in "Back In Style" along with Bugs Bunny, and Daffy Duck.
- Taz appears in "Episode 29: Draculee, Draculaa/Phranken-Runt" and "Episode 84: Cutie and the Beast/Boo Happens/Noel."