Animaniacs Wiki
Animaniacs Wiki
Main Page

If you're looking for the Pinky and the Brain spin-off series, go here

For other uses of the term Pinky and the Brain; click here

Pinky and the Brain is a recurring segment on Animaniacs focusing on Pinky and The Brain, two genetically-spliced lab mice who come up with various plans to take over the world. A running gag for this segment is where Brain asks Pinky if he is pondering what he is pondering; to which Pinky usually replies with something drastically different from Brain's thoughts.

In 1995, they were later spun-off into their own series with the same title, that lasted until 1998. However, while they had their own series, they still sporadically appeared in Animaniacs. Their spin-off series, in turn, spun-off another series called Pinky, Elmyra and the Brain (adding Elmyra Duff) which did not fare well with the audience or crew.

The segment returns in the 2020 reboot, structurally closer to the 1993 and 1995 shows with additional character/story developments. Following the reboot, the mice received a mini-series in 2023: The Brain Teaches World Domination (a promotional tie-in with MasterClass).

Theme Song

See here.


Pinky and the brain season 1 poster art

To prove their mousey worth, they'll overthrow the Earth...

Pinky and the Brain are two genetically-spliced lab mice that reside inside a cage in Acme Labs. The Brain is a genius and is mostly serious, but Pinky is goofy and energetic. Both have the desire to take over the world [note 1] and help each other out to fulfill their world domination goals with different schemes, but end up failing every time they do.[2] In some cases, the mice end up in more stranger situations and must save the world instead, in order to be able to conquer it the next day.


Only Animaniacs-related skits are listed here. For episodes from the 1995 series, see Episode Guide (Pinky and the Brain). For the shorts from the mini-series The Brain Teaches World Domination, see The Brain Teaches World Domination#Episodes.

Animaniacs (Original Series)

Animaniacs (Reboot)

Other appearances

Animaniacs (Original Series)


Animaniacs (Reboot)




  1. Pinky’s true ambitions are contradictory at best. He deduces in "Of Mice and Memes" that his and Brain’s relationship isn’t based on a shared desire to conquer the world, but rather his enabling of Brain’s systematic emotional and physical abuse. "Happy Narfday" however, shows "take over the world" is an item on Pinky's birthday list.


  1. This counts each part of multi-part cartoons as individual segments.
  2. Just Toys Animaniacs Bend-Ems Box Description
List of Segments
Animaniacs (1993-1998)
Yakko, Wakko, and Dot:
(Newsreel of the StarsWheel of MoralityThe Great WakkorottiDot's Poetry CornerTower Escapes, Chases, and ReturnsAnimator's AlleyUseless Facts)
Pinky and the BrainGoodfeathersSlappy SquirrelButtons and MindyRita and RuntChicken BooGood Idea, Bad Idea ("Skullhead Boneyhands") • Mime TimeMinerva MinkRandy BeamanThe Hip HipposThe FlameMiscellaneous (Stingers) • Ensemble shorts
Animaniacs (2020-2023)
Yakko, Wakko, and Dot (Math-Terpiece TheaterEveryday Safety) • Pinky and the BrainStarbox and CindyThe Incredible Gnome in People's MouthsSlappy SquirrelMiscellaneous