Animaniacs Wiki
Animaniacs Wiki

If you're looking for the Pinky and the Brain spin-off series, go here.

Pinky and the Brain is a recurring segment on Animaniacs focusing on Pinky and The Brain, two genetically-spliced lab mice who come up with various plans to take over the world. A running gag for this segment is where Brain asks Pinky if he is pondering what he is pondering; to which Pinky usually replies with something drastically different from Brain's thoughts.

In 1995, they were later spun-off into their own series with the same title, that lasted until 1998. However, while they had their own series, they still sporadically appeared in Animaniacs.

Their spin-off series, in turn, spun-off another series called Pinky, Elmyra and the Brain (adding Elmyra Duff) which did not fare well with the audience or crew.

The segment returns in the 2020 reboot, structurally closer to the 1993 and 1995 shows with additional character developments.


Pinky and the Brain are two tiny lab mice. Brain is a genius, but Pinky is just goofy. Both have the desire to take over the world [1]. But they fail each time they try.[2]


Only Animaniacs-related skits are listed here. Segments from the spin-off series are under their own Episode Guide

Animaniacs (Original Series)

  1. Win Big (Season 1, Episode 2C)
  2. Where Rodents Dare (Season 1, Episode 9B)
  3. Battle for the Planet (Season 1, Episode 15B)
  4. Pavlov's Mice (Season 1, Episode 18A)
  5. Opportunity Knox (Season 1, Episode 24A)
  6. Jockey for Position (Season 1, Episode 27C)
  7. Bubba Bo Bob Brain (Season 1, Episode 34B)
  8. Spellbound (Season 1, Episode 38)
  9. Puppet Rulers (Season 1, Episode 40C)
  10. The World Can Wait (Season 1, Episode 44B)
  11. When Mice Ruled the Earth (Season 1, Episode 47B)
  12. Yes, Always (Season 1, Episode 52C)
  13. Brain Meets Brawn (Season 1, Episode 54A)
  14. The Helpinki Formula (Season 1, Episode 56B)
  15. Meet John Brain (Season 1, Episode 58A)
  16. Cranial Crusader (Season 1, Episode 60B)
  17. Don't Tread on Us (Season 3, Episode 8B)
  18. Hercules Unwound (Season 3, Episode 9C) (Crossover with Yakko, Wakko, and Dot's segment)
  19. Pinky and the Ralph (Season 4, Episode 6C) (with Ralph T. Guard in place of the Brain)
  20. The Brain's Apprentice (Season 5, Episode 8B)

Animaniacs (Reboot)

  1. Of Mice and Memes (Season 1, Episode 1C)
  2. How to Brain Your Dragon (Season 1, Episode 2B)
  3. Pinko and the Brain (Season 1, Episode 3B)
  4. Ex-Mousina (Season 1, Episode 4B)
  5. No Brainer (Season 1, Episode 5B)
  6. Close Encounters of the Worst Kind (Season 1, Episode 6B)
  7. Mousechurian Candidate (Season 1, Episode 8B)
  8. Future Brain (Season 1, Episode 9C)
  9. Babysitter's Flub (Season 1, Episode 10B)
  10. Bride of Pinky (Season 1, Episode 11C)
  11. 1001 Narfs (Season 1, Episode 12B)
  12. Roadent Trip (Season 1, Episode 13B)
  13. Backwards Pinky (Season 2, Episode 1B)
  14. The Flawed Couple (Season 2, Episode 2B)
  15. Run Pinky Run (Season 2, Episode 3B)
  16. How To: Brain Takes Over The World (Season 2, Episode 4C)
  17. The Pinktator (Season 2, Episode 5B)
  18. Mouse Congeniality (Season 2, Episode 6B)
  19. Happy Narfday (Season 2, Episode 7C)
  20. Plight of Hand (Season 2, Episode 8B)
  21. Mouse Madness (Season 2, Episode 9B)
  22. Reichenbrain Falls (Season 2, Episode 10B)
  23. The Prisoner's Dilemma (Season 2, Episode 11C)
  24. Narf Over Troubled Water (Season 2, Episode 12C)

Other appearances

Original Series






  1. Pinky’s true ambitions are contradictory at best. He deduces in "Of Mice and Memes" that his and Brain’s relationship isn’t based on a shared desire to conquer the world, but rather his enabling of Brain’s systematic emotional and physical abuse. "Happy Narfday" however, shows "take over the world" is an item on Pinky's birthday list.
  2. Just Toys Animaniacs Bend-Ems Box Description
List of Segments
Animaniacs (1993-1998)
Yakko, Wakko, and Dot (Wheel of MoralityThe Great WakkorottiAnimator's AlleyUseless Facts) • Pinky and the BrainGoodfeathersSlappy SquirrelButtons and MindyRita and RuntChicken BooGood Idea, Bad Idea ("Skullhead Boneyhands") • Mime TimeMinerva MinkRandy BeamanThe Hip HipposThe FlameMiscellaneousEnsemble shorts
Animaniacs (2020-)
Yakko, Wakko, and Dot (Math-Terpiece Theater) • Pinky and the BrainStarbox and CindyThe Incredible Gnome in People's MouthsMiscellaneous